Targeted brain stimulation
Magnetic pulses from the H-coil reach broader and deeper brain regions than standard rTMS, directly engaging structures tied to depression.
FDA-Cleared Deep TMS
TMS Therapy for Depression
A safe, non-invasive, medication-free path to relief from major depressive disorder — even when other treatments have fallen short.
What is Deep TMS?
A revolution in depression care
Deep Transcranial Magnetic Stimulation (Deep TMS™) is an FDA-cleared treatment for Major Depressive Disorder (MDD). Using a patented H-coil housed in a cushioned helmet, Deep TMS delivers gentle magnetic pulses that reach broad and deep brain regions involved in mood regulation — most notably the dorsolateral prefrontal cortex (DLPFC).
Peer-reviewed studies have shown Deep TMS to produce meaningful, lasting improvement in symptoms of depression — often in patients who have not responded to medication or talk therapy alone.
FDA-cleared since 2013
Targets the DLPFC
20-minute sessions
No anesthesia or downtime
Depression by the Numbers
A widespread condition with a real solution
1 in 15
U.S. adults affected by depression each year
17.3M
Americans report a major depressive episode
~1 in 3
Treatment-resistant patients achieve remission with Deep TMS
~4 in 5
Achieve a clinical response after 30+ sessions
How It Works
Re-engaging the brain’s mood circuits
Restored neural activity
Regulating activity in the dorsolateral prefrontal cortex (DLPFC) helps re-balance the mood-regulating circuits that depression disrupts.
Sustained symptom relief
Clinical research shows lasting improvement in depressive symptoms — and a meaningful boost in day-to-day quality of life.
Proven Efficacy
Backed by peer-reviewed research
Deep TMS is one of the most rigorously studied non-invasive treatments for depression. Its efficacy has been demonstrated across multicenter trials and years of real-world clinical practice.
- Independent 2019 study in the Journal of Psychiatric Research found Deep TMS + medication significantly more effective than rTMS + medication or medication alone.
- A 2015 multicenter sham-controlled trial in World Psychiatry confirmed Deep TMS's efficacy in treatment-resistant MDD, independent of medication effects.
- Nearly 80% of patients who did not immediately respond in the acute phase improved during the continuation phase.
- Real-world data from 1,300+ patients shows ~4 in 5 achieve a clinical response and ~2 in 3 achieve remission after 30+ sessions.
Safety Profile
A well-tolerated, non-invasive treatment
Deep TMS has not been shown to cause any substantial or lasting side effects. Most patients describe a mild tapping sensation during treatment and resume their day immediately after each session — no anesthesia, no sedation, no recovery time.
Most common side effects
- Application-site pain~25%
- Application-site discomfort~19%
- Jaw pain~10%
Side effects typically subside shortly after the first few treatment sessions.
Treatment Protocols
Flexible plans that fit your life
Standard Protocol
20-minute sessions · 4–6 weeks acute phase
Daily sessions over approximately four weeks, followed by periodic maintenance sessions to sustain results. An alternative 3-minute intermittent theta burst (iTBS) option is also available.
SWIFT™ Accelerated Protocol
10-minute sessions · 6-day acute phase
FDA-cleared accelerated option: five 10-minute sessions per day, spaced at least 50 minutes apart, for 6 days — shown to be as effective as the standard protocol, followed by a continuation phase.
Ready to take the next step?
If depression has held you back, Deep TMS therapy at Chrysalis TMS Institute may offer the relief you’ve been searching for. Speak with our team to learn whether TMS is right for you.